The July issue of SLAS Discovery features a new method for detecting metal impurities in high-throughput screening – available now


News — Oak Brook, Illinois – The July issue of SLAS Discovery is now available in open access on ScienceDirect.

A challenge that researchers often face when using high-throughput screening (HTS) to identify new therapeutic compounds is the high number of false positives resulting from compounds contaminated with metals. When compounds containing metal impurities produce false positives, researchers must spend valuable time and resources testing these compounds rather than focusing on a smaller number of more auspicious results. To help triage HTS hits, the authors of “High-throughput detection of metal contamination in HTS outputs” by Molyneux, et al. use a method of using acoustic fog ionization mass spectrometry to identify eight different metal contaminants. This technique is more desirable than previous methods, which either fail to identify specific metals or require many steps that are not compatible with high-throughput methods. Access the article to learn about the success of the described method in identifying metal impurities compared to previous methods, and how AstraZeneca uses this high-throughput detection technique.

The July issue of SLAS Discovery includes the following items:

Access the July issue of SLAS Discovery is available at


SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life science researchers, developers and suppliers of laboratory automation technologies. The mission of SLAS is to bring together researchers from academia, industry and government to advance life science discovery and technology through education, knowledge exchange and global community building. .

SLAS Discovery: advancing the science of drug discovery, Impact factor 2021 3.341. Managing Editor Robert M. Campbell, Ph.D., Twentyeight-Seven Therapeutics, Watertown, MA (USA)



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